I will say this about suffering... it is very hard to know joy unless you know suffering and sadness. Not saying you should seek out suffering and sadness, but if you've been through it and you've also found joy on the other side then you probably know what I'm talking about.
As for the end of life, try to think of it this way... even a year of pain and suffering is just a blip in the span of eternity. "This too shall pass."
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