I use WordPress. There's a link to my site in my signature. It took me about a week to get that set up properly, but I had a lot of customization to do.
My Host has one-click WP installation, so that was easy. I also like all the free themes and plug-ins for WP.
But as with any third-party code, I have learned to thoroughly function test my site after installing a new plug-in. Most of them are great, but a few of them have caused problems for me.
Also, be aware that certain themes may have compatibility issues with certain plug-ins, and certain plug-ins may have compatibility issues with each other. This is common sense, but worth mentioning for a new guy. Most of my experiences with plug-ins have been fantastic.
Good luck with your blog!