This thread discussion caused me to think of the hypothesized links between LSD and the Salem Witch Trials. Whether or not the bizarre behavior and visions claimed by the accused witches were actually drug-induced states remains a mystery, at the same time as an intriguing possibility:
Ergot Poisoning (LSD) - the cause of the Salem Witch Trials - PBS Secrets of the Dead Ask Erowid : ID 2167 : Were the Salem Witch Trials drug induced?