I guarantee I could find ways to blow through lots of it materially...
But-
honestly, I would do lots for myself and my loved ones in a material sense.
But even my fantasies can be accomplished with much less than a billion, so yes, there'd be definite charitable goals - I'd help fund this charter school Nneka's discussing

, set up foundations for education, disease research, peace, human rights, act as an anonymous "angel" for many less fortunate - e.g. shelter for homeless, pay off debts for working poor, build a business which could create a wide spread of jobs, I liked the angel-investor idea.
In all of this, of course, lawyers and accountants would be hired to manage it - protection, investment, tracking, etc.