The E-myth does a good job of discussing how a brick and mortar business can be run as a system but does little to cover the needs for internet businesses.
Several month's back the Internet Marketer, Rich Schefren, had several popular downloads addressing the systematization of an Internet Business. He directly addresses the E-Myth in some of these free downloads.
Here is a link to a good write up of them
The Internet Business Manifesto + Missing Chapter » Internet Marketing | Entrepreneurs-Journey.com - by Yaro Starak Two More Great Internet Business Resources From Rich Schefren » Internet Marketing | Entrepreneurs-Journey.com - by Yaro Starak Rich Schefren’s ‘The Final Chapter Of The Internet Business Manifesto’ » Internet Marketing | Entrepreneurs-Journey.com - by Yaro Starak