I have several email address. I have 2 websites, and each of those sites have their own email address. Infact, some of those sites have multiple emails eg.
feedback@domain.com ,
info@domain.com
Then I have another email address for personal emails between friends, family and just general stuff. I use gmail for this, rather than a site email or from my internet provider, because I know i will always have this email regardless if I change providers or cancel my domain.
I have another email address for when I sign up to websites and competitons because I dont want my site or personal email to become the victim of spam
All these email address have been set up to work within outlook, getting directed to their own folder.
I dont use my website email address for anything but for the purpose of the website, that way if the website closes in a year or so, I still have an active gmail email and I would only loose emails that are on the subject of the closed website.