Some people do disable javascript. At the last company I worked for, everything had to work with javascript disabled. I guess they had enough prospects that turned it off to lose enough business to worry about it. However, before I left the company, they were talking about doing away with designing for the javascript disabled. They felt that since the product itself required javascript that it was silly to allow people to sign up for the product without it. It was like we were providing an inconsistent message. They did want to make it very clear during the sign-up process that javascript would be required, though, so as not to cause people to have an unfavorable experience. I would suggest that if you are deciding you don't want to deal with the javascript disabled people that you still practice graceful degradation and make it clear when javascript is absolutely required.
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