Just a few quick things I noticed on first glance. First a little information. I'm running a 1280 by 800 resolution, so not too big.
The first thing I don't like about the layout is that the ads appeared centred on my page with the content all the way over on the left. This makes it feel like the content is an afterthought and the ads are the primary concern. Secondly, the Title of the blog is on the right, so I automatically looked below that for the content and was met with a blank space. You could try centering the content and ads so that the page feels a little more balanced.
If you don't want to move the columns, simply shifting the title to the right hand side of the screen should make a big difference.
The other thing I noticed is that the Title seems to blend into the heading bar. Try changing it to match the background colour or some other light colour that fits your theme. If you want to match the colours exactly, there's a nifty little programme called colour picker.
Otherwise, the content looks good, and good content will always overshadow bad design in the long run.