Multiple themes for a website is not an issue, except perhaps for search engines trying to "typecast" your site. For a blog, however, it's probably best to separate them, since people tuning in would be doing so on account of a particular topic and not necessarily some other one out of all that you're interested in...unless you manage to sell your persona such that most anything you have to say would be of some interest because people think of you in personal terms (like how fans want to know all those things about celebrities).
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