To me, it's more about accepting that things aren't always ideal. I post a lot on another forum, and if enough people don't like your post, it gets deleted. First few times it happened, I was quite unhappy about it. Felt like violation.
Nowadays, I'm kind of grateful for it. I'm a whole lot less sensitive over deleted posts, neg reps, and the whole like. It's just feedback and it doesn't mean anything about us personally. I wish I'd had these experiences sooner in life.
About seven years ago, I went to school for a career I absolutely loved. When it came practicum time, the criticism of my preceptors drove me directly out of that vocation. I still completed it, as a show for friends and family, but inside, I was done with it. I left that career behind and never looked back.
Would neg reps have made the difference? Probably not on their own. However, I was so quick to take everything personally that I shot myself in the foot. I think it's a good thing to become comfortable with uncomfortable feedback. Again, it means nothing about you... unless you take it to mean something.