Zeloc,
If you have to ask, then, most likely, you do not have your obsession.
So, at least for now, I'd advise you to go with balanced goal list. One of the goals on this list may be to develop the obsession.
We admire the geniuses who had only one dream in mind, but we forget that they have developed their obsession spontaneously. And we do forget about their tragic destinies.
If the most important goal will become clear to you, you will know. And then you will be able to align all other goals in relation to the one, if you want to.